Across TCGA cell cohorts, CLCNKB mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCNKB-associated genes across cancer lineages are OR51T1, GSG1L2, and OR1A2. Each is linked with CLCNKB in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCNKB-to-partner and partner-to-CLCNKB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCNKB→partner) and Y-score (partner→CLCNKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.017	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	CCL18 →	+0.026	+4.212	.005	.007	3	1
LARGE_INTESTINE	GRM6 →	+0.090	+3.115	<.001	.004	3	1
LARGE_INTESTINE	ADRA1A →	+0.122	+3.103	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

CLCNKB survival (RNA) · tumor vs normal (RNA) · all CLCNKB data types