Across TCGA pan-cancer cohorts, CLCNKA mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CLCNKA data layer compared with 19 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CLCNKA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CLCNKA expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where CLCNKA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.177	.006	8	view →
HNSC	OS	Median	III,IV	1.000	0.791	.023	6	view →
CCRCC	DFS	Quartile	All	1.000	0.667	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: CLCNKA tumor-vs-normal RNA expression · all CLCNKA data types