Across TCGA patient cohorts, CLCNKA mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCNKA-associated genes across cancer lineages are FOXO3a, Caveolin-1, and ERK2. Each is linked with CLCNKA in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCNKA-to-partner and partner-to-CLCNKA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCNKA→partner) and Y-score (partner→CLCNKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.082	-1.670	.045	.042	3	3
SKCM	Caveolin-1 →	-0.774	-3.169	.006	.017	3	2
UCEC	ERK2 →	+0.241	+2.906	.001	.001	3	1
UCEC	Notch1 →	+0.136	+2.335	.016	.018	3	1
UCEC	N-Ras →	-0.096	-1.893	.046	.016	3	1
UCEC	p27_pT157 →	-0.068	-2.545	.003	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

CLCNKA survival (RNA) · tumor vs normal (RNA) · all CLCNKA data types