CLCN6

Across TCGA pan-cancer cohorts, CLCN6 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CLCN6’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CLCN6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CLCN6 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, CCRCC, and LUAD are the cancer types where CLCN6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLCN6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	−0.523	<.001	8	view →
CCRCC	Male	All	+0.313	<.001	8	view →
LUAD	Male	All	−0.494	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CLCN6–LSCC

Open the LSCC breakdown →