CLCN6

Across TCGA patient cohorts, CLCN6 protein abundance is significantly associated with the RNA expression of many other genes, with 11,329 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLCN6-associated genes across cancer lineages are KCNMB2, TYW1B, and PEMT. Each is linked with CLCN6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN6-to-partner and partner-to-CLCN6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLCN6 versus KCNMB2 in HNSC, with a Pearson correlation of -0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN6→partner) and Y-score (partner→CLCN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KCNMB2 →	-1.336	-0.520	.003	.002	3	2
OV	TYW1B →	+0.827	+0.818	<.001	.006	3	2
HNSC	PEMT →	-0.788	-0.520	.003	.002	3	2
GBM	TTYH1 →	+0.880	+0.230	<.001	.001	3	2
GBM	CAMTA1 →	+0.609	+0.315	<.001	<.001	3	2
GBM	PNMA5 →	+0.400	+0.306	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,329 associations by consensus.

CLCN6 vs KCNMB2 — HNSC

Explore this scatter interactively →