CLCN6

Across TCGA patient cohorts, CLCN6 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN6-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and ATM. Each is linked with CLCN6 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLCN6-to-partner and partner-to-CLCN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CLCN6-low versus CLCN6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN6→partner) and Y-score (partner→CLCN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.684	+2.604	<.001	<.001	3	4
COAD	PCNA →	+0.273	+3.008	.034	.019	3	2
UCEC	ATM →	-0.691	-2.489	<.001	.001	3	2
UCEC	eEF2 →	+0.230	+1.289	.044	.023	3	2
UCEC	EGFR_pY1068 →	-0.168	-1.289	.035	.023	3	2
UCEC	GAPDH →	+0.339	+1.502	.048	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by CLCN6 expression — UCEC

Explore this box plot interactively →