CLCN6

Across TCGA cell cohorts, CLCN6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,592 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CLCN6-associated GO terms across cancer lineages are Microtubule nucleation, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Establishment of mitotic spindle localization. Each is linked with CLCN6 in more than 16 cancer types. Because this analysis shows association rather than direction, both CLCN6-to-partner and partner-to-CLCN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule nucleation grouped by CLCN6-low versus CLCN6-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN6→partner) and Y-score (partner→CLCN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Microtubule nucleation →	+0.133	+1.109	<.001	<.001	3	17
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.152	+0.715	<.001	<.001	3	16
BONE	Establishment of mitotic spindle localization →	+0.127	+1.053	<.001	<.001	3	16
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.147	+0.690	<.001	<.001	3	16
LUNG_SCLC	Endosomal transport →	+0.054	+0.996	<.001	<.001	3	15
LARGE_INTESTINE	Cytosolic transport →	+0.065	+1.121	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,592 associations by consensus.

Microtubule nucleation by CLCN6 expression — LARGE_INTESTINE

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