CLCN6

Across TCGA cell cohorts, CLCN6 mutation is significantly associated with the RNA expression of many other genes, with 571 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCN6-associated genes across cancer lineages are AVP, IQCF5, and TEX46. Each is linked with CLCN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN6-to-partner and partner-to-CLCN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by CLCN6-low versus CLCN6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN6→partner) and Y-score (partner→CLCN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AVP →	+0.040	+4.734	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	2
LARGE_INTESTINE	TEX46 →	+0.142	+3.887	<.001	<.001	3	2
LARGE_INTESTINE	CD300H →	+0.016	+2.678	<.001	.005	3	2
LARGE_INTESTINE	GUCA1A →	+0.031	+3.300	.003	<.001	3	2
BLOOD_Lymphoma	FGF21 →	+0.084	+3.956	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 571 associations by consensus.

AVP by CLCN6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →