CLCN4

Across TCGA patient cohorts, CLCN4 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,013 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLCN4-associated proteins across cancer lineages are SNX4, DNMBP, and FLNB_S1505. Each is linked with CLCN4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLCN4-to-partner and partner-to-CLCN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLCN4 versus SNX4 in CCRCC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN4→partner) and Y-score (partner→CLCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SNX4 →	+0.272	+0.641	<.001	<.001	3	4
HNSC	DNMBP →	-0.295	-0.683	<.001	<.001	3	4
GBM	FLNB_S1505 →	-0.996	-0.526	.001	.003	3	4
CCRCC	HSD17B11 →	+0.513	+0.637	<.001	<.001	3	4
HNSC	MAOB →	+0.519	+0.700	<.001	<.001	3	4
BRCA	PRKCQ_T538 →	+1.235	+1.010	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,013 associations by consensus.

CLCN4 vs SNX4 — CCRCC

Explore this scatter interactively →