CLCN4

Across TCGA patient cohorts, CLCN4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,479 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLCN4-associated genes across cancer lineages are SH3GL2, CACNG7, and FUBP1. Each is linked with CLCN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN4-to-partner and partner-to-CLCN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLCN4 versus SH3GL2 in GBM, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN4→partner) and Y-score (partner→CLCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SH3GL2 →	+1.392	+0.428	<.001	<.001	3	2
CCRCC	CACNG7 →	-0.036	-0.422	<.001	.009	3	1
CCRCC	FUBP1 →	-0.604	-0.606	.007	.007	3	1
CCRCC	WDR26 →	-0.535	-0.606	<.001	.007	3	1
CCRCC	ZG16 →	-0.036	-0.422	<.001	.009	3	1
CCRCC	NPM1P14 →	-0.126	-0.422	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,479 associations by consensus.

CLCN4 vs SH3GL2 — GBM

Explore this scatter interactively →