CLCN4

Across TCGA patient cohorts, CLCN4 mutation is significantly associated with the RNA expression of many other genes, with 4,469 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN4-associated genes across cancer lineages are ITGAE, RNU6-633P, and KRTAP12-2. Each is linked with CLCN4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLCN4-to-partner and partner-to-CLCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAE grouped by CLCN4-low versus CLCN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN4→partner) and Y-score (partner→CLCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGAE →	+0.505	+2.321	<.001	<.001	3	4
BLCA	RNU6-633P →	+0.530	+3.266	<.001	.009	3	3
LUSC	KRTAP12-2 →	+0.083	+3.737	<.001	.003	3	3
STAD	RN7SKP181 →	+0.164	+2.784	.001	.008	3	3
COAD	TLE6 →	+0.535	+3.486	.004	.002	3	3
COAD	TMX1 →	+0.644	+3.459	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,469 associations by consensus.

ITGAE by CLCN4 expression — UCEC

Explore this box plot interactively →