CLCN4

Across TCGA patient cohorts, CLCN4 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN4-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and Chk1. Each is linked with CLCN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN4-to-partner and partner-to-CLCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CLCN4-low versus CLCN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN4→partner) and Y-score (partner→CLCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.508	+1.926	.009	.008	3	3
COAD	eIF4E →	+0.203	+2.195	.015	.034	3	2
COAD	Chk1 →	+0.246	+3.330	.019	.005	3	2
COAD	Cyclin-E1 →	+0.271	+2.820	.021	.035	3	2
UCEC	eEF2 →	+0.344	+1.906	.003	.015	3	2
UCEC	EGFR_pY1068 →	-0.250	-1.938	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by CLCN4 expression — UCEC

Explore this box plot interactively →