CLCN3

Across TCGA patient cohorts, CLCN3 protein abundance is significantly associated with the RNA expression of many other genes, with 8,355 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CLCN3-associated genes across cancer lineages are IRF4, AKT3, and MLKL. Each is linked with CLCN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both CLCN3-to-partner and partner-to-CLCN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLCN3 versus IRF4 in UCEC, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN3→partner) and Y-score (partner→CLCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRF4 →	-0.956	-0.332	.004	.003	3	5
UCEC	AKT3 →	-0.822	-0.279	<.001	.002	3	4
HNSC	MLKL →	-0.521	-0.319	.001	<.001	3	4
UCEC	MAP7D3 →	-0.794	-0.444	<.001	<.001	3	4
PDAC	FCRLA →	-0.945	-0.404	<.001	<.001	3	4
HNSC	MPEG1 →	-0.981	-0.262	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,355 associations by consensus.

CLCN3 vs IRF4 — UCEC

Explore this scatter interactively →