CLCN3

Across TCGA patient cohorts, CLCN3 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN3-associated genes across cancer lineages are Src_pY527, ATM, and JNK2. Each is linked with CLCN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLCN3-to-partner and partner-to-CLCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by CLCN3-low versus CLCN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN3→partner) and Y-score (partner→CLCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.417	-2.169	.001	.002	3	4
UCEC	ATM →	-0.612	-1.893	<.001	<.001	3	3
UCEC	JNK2 →	+0.254	+2.169	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.197	-3.156	<.001	<.001	3	2
UCEC	Notch1 →	+0.159	+1.643	<.001	.003	3	2
UCEC	p62 Lck ligand →	+0.431	+3.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Src_pY527 by CLCN3 expression — UCEC

Explore this box plot interactively →