CLCN3

Across TCGA cell cohorts, CLCN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,907 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLCN3-associated GO terms across cancer lineages are Endosomal lumen acidification, Negative regulation of chromosome condensation, and Cytosolic transport. Each is linked with CLCN3 in more than 15 cancer types. Because this analysis shows association rather than direction, both CLCN3-to-partner and partner-to-CLCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal lumen acidification grouped by CLCN3-low versus CLCN3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN3→partner) and Y-score (partner→CLCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Endosomal lumen acidification →	+0.135	+0.748	<.001	<.001	3	16
BLOOD_Lymphoma	Negative regulation of chromosome condensation →	+0.140	+0.990	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.062	+0.913	.006	.002	3	12
BLOOD_Lymphoma	Viral translational termination-reinitiation →	+0.094	+1.077	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.070	+0.992	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Endoplasmic reticulum to cytosol transport →	+0.116	+0.890	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,907 associations by consensus.

Endosomal lumen acidification by CLCN3 expression — KIDNEY

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