CLCN3

Across TCGA cell cohorts, CLCN3 mutation is significantly associated with the drug of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCN3-associated genes across cancer lineages are AZD8055, Rapamycin, and CAY10566. Each is linked with CLCN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN3-to-partner and partner-to-CLCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD8055 grouped by CLCN3-low versus CLCN3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN3→partner) and Y-score (partner→CLCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AZD8055 →	+0.461	+2.807	.042	.047	3	1
BREAST	Rapamycin →	+0.610	+2.667	.022	.040	3	1
BREAST	CAY10566 →	+0.325	+2.866	.004	.023	3	1
LARGE_INTESTINE	QL-XII-61 →	+0.429	+2.672	.015	.039	3	1
LARGE_INTESTINE	Pevonedistat →	+0.821	+2.871	.011	.021	3	1
LARGE_INTESTINE	Dactinomycin →	+0.534	+2.871	.015	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

AZD8055 by CLCN3 expression — BREAST

Explore this box plot interactively →