CLCN2

Across TCGA patient cohorts, CLCN2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,004 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLCN2-associated genes across cancer lineages are MAPRE1, EIF4G1, and TTPAL. Each is linked with CLCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN2-to-partner and partner-to-CLCN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLCN2 versus MAPRE1 in LSCC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN2→partner) and Y-score (partner→CLCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAPRE1 →	+0.577	+0.592	.008	.002	3	2
LSCC	EIF4G1 →	+1.021	+0.738	<.001	<.001	3	2
LSCC	TTPAL →	+0.636	+0.451	.001	.003	3	2
LSCC	CSE1L →	+0.829	+0.578	<.001	<.001	3	2
LSCC	MOCS3 →	+0.560	+0.338	<.001	.008	3	2
LSCC	ATP13A3 →	+0.793	+0.530	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,004 associations by consensus.

CLCN2 vs MAPRE1 — LSCC

Explore this scatter interactively →