CLCN2

Across TCGA patient cohorts, CLCN2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN2-associated genes across cancer lineages are ATM, mTOR_pS2448, and NF2. Each is linked with CLCN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN2-to-partner and partner-to-CLCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CLCN2-low versus CLCN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN2→partner) and Y-score (partner→CLCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.541	-2.392	<.001	<.001	3	3
UCEC	mTOR_pS2448 →	-0.112	-2.209	.034	.009	3	2
UCEC	NF2 →	+0.200	+1.362	.008	.037	3	2
UCEC	PCNA →	+0.278	+2.392	<.001	<.001	3	2
UCEC	Tuberin →	+0.289	+1.362	.002	.037	3	2
UCEC	Caspase-7-cleavedD198 →	+0.673	+1.827	.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by CLCN2 expression — UCEC

Explore this box plot interactively →