CLCN2

Across TCGA cell cohorts, CLCN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,474 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLCN2-associated GO terms across cancer lineages are Regulation of membrane depolarization during action potential, Negative regulation of translational initiation, and Pre-mRNA catabolic process. Each is linked with CLCN2 in more than 12 cancer types. Because this analysis shows association rather than direction, both CLCN2-to-partner and partner-to-CLCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of membrane depolarization during action potential grouped by CLCN2-low versus CLCN2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN2→partner) and Y-score (partner→CLCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of membrane depolarization during action potential →	+0.190	+1.464	<.001	<.001	3	13
BONE	Negative regulation of translational initiation →	+0.141	+1.223	<.001	.001	3	13
BONE	Pre-mRNA catabolic process →	+0.177	+1.003	<.001	<.001	3	12
SOFT_TISSUE	Copper ion export →	-0.168	-1.093	<.001	<.001	3	11
BONE	Regulation of transcription by RNA polymerase I →	+0.107	+0.884	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Glycerophospholipid metabolic process →	+0.046	+1.108	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,474 associations by consensus.

Regulation of membrane depolarization during action potential by CLCN2 expression — LIVER

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