CLCN2

Across TCGA cell cohorts, CLCN2 mutation is significantly associated with the RNA expression of many other genes, with 511 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCN2-associated genes across cancer lineages are STOX1, H2BC1, and LCE2B. Each is linked with CLCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN2-to-partner and partner-to-CLCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STOX1 grouped by CLCN2-low versus CLCN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN2→partner) and Y-score (partner→CLCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	STOX1 →	+0.972	+3.502	.002	.001	3	2
SOFT_TISSUE	H2BC1 →	+0.216	+3.977	<.001	.007	3	1
SOFT_TISSUE	LCE2B →	+0.020	+3.977	<.001	.007	3	1
SOFT_TISSUE	H2AC1 →	+0.096	+3.977	<.001	.007	3	1
BLOOD_Leukemia	CST4 →	+0.044	+3.187	<.001	.001	3	1
BLOOD_Leukemia	ST8SIA2 →	+0.551	+4.169	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 511 associations by consensus.

STOX1 by CLCN2 expression — LARGE_INTESTINE

Explore this box plot interactively →