Across TCGA patient cohorts, CLCN1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN1-associated genes across cancer lineages are Notch1, C-Raf, and Heregulin. Each is linked with CLCN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN1-to-partner and partner-to-CLCN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN1→partner) and Y-score (partner→CLCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Notch1 →	+0.124	+2.182	.009	.033	3	3
UCEC	C-Raf →	+0.124	+1.378	.003	.008	3	3
SKCM	Heregulin →	+0.129	+1.260	.013	.025	3	3
UCEC	PDCD4 →	-0.494	-2.415	<.001	.002	3	3
UCEC	Caspase-8 →	-0.258	-3.497	<.001	<.001	3	3
LUAD	Bid →	+0.122	+3.000	.006	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

CLCN1 survival (RNA) · tumor vs normal (RNA) · all CLCN1 data types