Across TCGA cell cohorts, CLCN1 RNA expression is significantly associated with the RNA expression of many other genes, with 2,718 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CLCN1-associated genes across cancer lineages are PIK3IP1, C1QBP, and IL1RN. Each is linked with CLCN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLCN1-to-partner and partner-to-CLCN1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN1→partner) and Y-score (partner→CLCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PIK3IP1 →	+1.926	+0.537	.002	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	C1QBP →	-1.101	-0.291	<.001	.001	3	3
PANCREAS	IL1RN →	+2.353	+0.156	<.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	PTGES →	+3.008	+0.499	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	IKZF2 →	+1.580	+0.454	<.001	.002	3	3
BLOOD_Leukemia	P2RY2 →	+2.479	+0.240	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,718 associations by consensus.

Exploration

CLCN1 survival (RNA) · tumor vs normal (RNA) · all CLCN1 data types