Across TCGA cell cohorts, CLCN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,356 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CLCN1-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Protein stabilization. Each is linked with CLCN1 in more than 7 cancer types. Because this analysis shows association rather than direction, both CLCN1-to-partner and partner-to-CLCN1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN1→partner) and Y-score (partner→CLCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of syncytium formation by plasma membrane fusion →	+0.073	+0.102	<.001	.002	3	8
LUNG_NSCLC_LUAD	Negative regulation of myoblast fusion →	+0.075	+0.102	<.001	.002	3	7
BREAST	Protein stabilization →	+0.053	+0.176	<.001	.008	3	6
KIDNEY	Negative regulation of molecular function →	+0.042	+0.024	.006	.009	3	6
UPPER_AERODIGESTIVE_TRACT	Cell-substrate junction organization →	+0.167	+0.503	<.001	.002	3	6
CNS	Regulation of RNA splicing →	+0.049	+0.022	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,356 associations by consensus.

Exploration

CLCN1 survival (RNA) · tumor vs normal (RNA) · all CLCN1 data types