Across TCGA cell cohorts, CLCN1 mutation is significantly associated with the RNA expression of many other genes, with 566 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCN1-associated genes across cancer lineages are HSCB, SGSM3, and METTL4. Each is linked with CLCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN1-to-partner and partner-to-CLCN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN1→partner) and Y-score (partner→CLCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSCB →	+0.553	+3.584	.001	<.001	3	2
LARGE_INTESTINE	SGSM3 →	+0.590	+3.307	.006	.003	3	2
LARGE_INTESTINE	METTL4 →	+0.476	+3.237	.007	.003	3	2
LARGE_INTESTINE	ENOSF1 →	+0.759	+2.404	.004	.004	3	2
LARGE_INTESTINE	PRMT9 →	+0.542	+2.514	<.001	.005	3	2
LARGE_INTESTINE	PHKA1 →	+0.660	+3.321	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 566 associations by consensus.

Exploration

CLCN1 survival (RNA) · tumor vs normal (RNA) · all CLCN1 data types