CLCF1

Across TCGA patient cohorts, CLCF1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCF1-associated genes across cancer lineages are EGFR_pY1068, Notch1, and p21. Each is linked with CLCF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCF1-to-partner and partner-to-CLCF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CLCF1-low versus CLCF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCF1→partner) and Y-score (partner→CLCF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.348	-3.000	.008	.036	3	1
UCEC	Notch1 →	+0.255	+3.013	<.001	.018	3	1
UCEC	p21 →	+0.234	+3.000	.020	.036	3	1
UCEC	p62 Lck ligand →	+0.528	+3.009	.001	.019	3	1
UCEC	PKC-a →	+0.662	+2.820	.001	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+1.024	+2.999	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by CLCF1 expression — UCEC

Explore this box plot interactively →