CLCF1

Across TCGA cell cohorts, CLCF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,749 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CLCF1-associated GO terms across cancer lineages are Regulation of isotype switching to IgE isotypes, Positive regulation of isotype switching to IgE isotypes, and Urokinase plasminogen activator signaling pathway. Each is linked with CLCF1 in more than 17 cancer types. Because this analysis shows association rather than direction, both CLCF1-to-partner and partner-to-CLCF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of isotype switching to IgE isotypes grouped by CLCF1-low versus CLCF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCF1→partner) and Y-score (partner→CLCF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of isotype switching to IgE isotypes →	+1.597	+2.373	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgE isotypes →	+1.597	+2.373	<.001	<.001	3	18
BREAST	Urokinase plasminogen activator signaling pathway →	+0.962	+1.236	<.001	<.001	3	14
BONE	Positive regulation of cell-substrate adhesion →	+0.147	+1.732	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of cell junction assembly →	+0.109	+1.302	<.001	<.001	3	13
BONE	Oncostatin-M-mediated signaling pathway →	+0.201	+1.707	.001	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,749 associations by consensus.

Regulation of isotype switching to IgE isotypes by CLCF1 expression — LUNG_NSCLC_LUSC

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