CLCA2

Across TCGA patient cohorts, CLCA2 mutation is significantly associated with the RNA expression of many other genes, with 4,608 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCA2-associated genes across cancer lineages are BTBD6, ZFP91, and ERCC6L. Each is linked with CLCA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCA2-to-partner and partner-to-CLCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTBD6 grouped by CLCA2-low versus CLCA2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCA2→partner) and Y-score (partner→CLCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BTBD6 →	+0.565	+2.613	<.001	.005	3	3
UCEC	ZFP91 →	+0.454	+2.043	.002	.001	3	3
UCEC	ERCC6L →	+0.601	+1.857	<.001	<.001	3	3
UCEC	WDHD1 →	+0.697	+2.120	<.001	<.001	3	3
UCEC	DCLRE1A →	+0.354	+1.879	.005	<.001	3	3
UCEC	CHUK →	+0.346	+1.823	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,608 associations by consensus.

BTBD6 by CLCA2 expression — SKCM

Explore this box plot interactively →