CLCA2

Across TCGA patient cohorts, CLCA2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCA2-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and p27_pT198. Each is linked with CLCA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCA2-to-partner and partner-to-CLCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CLCA2-low versus CLCA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCA2→partner) and Y-score (partner→CLCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.570	+3.189	.002	<.001	3	3
UCEC	MEK1 →	+0.348	+2.169	.002	.003	3	2
LUAD	p27_pT198 →	+0.143	+2.824	.019	.034	3	1
UCEC	14-3-3_beta →	-0.102	-2.880	.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.256	-1.777	.001	.002	3	1
UCEC	eIF4E →	+0.138	+3.335	.040	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by CLCA2 expression — UCEC

Explore this box plot interactively →