CLCA2

Across TCGA cell cohorts, CLCA2 mutation is significantly associated with the RNA expression of many other genes, with 195 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCA2-associated genes across cancer lineages are PDCL2, PRR20B, and PRR20A. Each is linked with CLCA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCA2-to-partner and partner-to-CLCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCL2 grouped by CLCA2-low versus CLCA2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCA2→partner) and Y-score (partner→CLCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PDCL2 →	+0.402	+3.930	<.001	.003	3	2
BLOOD_Lymphoma	PRR20B →	+0.114	+4.643	<.001	.005	3	2
BLOOD_Lymphoma	PRR20A →	+0.114	+4.643	<.001	.005	3	2
BLOOD_Lymphoma	PRR20D →	+0.114	+4.643	<.001	.005	3	2
BLOOD_Lymphoma	PRR20E →	+0.114	+4.643	<.001	.005	3	2
LUNG_NSCLC_LUAD	OR6C2 →	+0.344	+4.189	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 195 associations by consensus.

PDCL2 by CLCA2 expression — SKIN

Explore this box plot interactively →