CLBA1

Across TCGA patient cohorts, CLBA1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLBA1-associated genes across cancer lineages are PCNA, ER-alpha, and MEK1. Each is linked with CLBA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLBA1-to-partner and partner-to-CLBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CLBA1-low versus CLBA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLBA1→partner) and Y-score (partner→CLBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.281	+3.584	.007	.002	3	2
UCEC	ER-alpha →	-0.793	-3.169	.046	.019	3	1
UCEC	MEK1 →	+0.430	+2.999	.015	.035	3	1
UCEC	p27_pT198 →	+0.116	+3.169	.025	.019	3	1
UCEC	AR →	-0.428	-2.459	.017	.020	3	1
UCEC	4E-BP1_pT37_T46 →	-0.527	-3.156	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PCNA by CLBA1 expression — UCEC

Explore this box plot interactively →