CLASP2

Across TCGA pan-cancer cohorts, CLASP2 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CLASP2 data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CLASP2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CLASP2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and PDAC are the cancer types where CLASP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.778	0.287	<.001	52	view →
COAD	DFS	Quartile	II,III,IV	1.000	0.876	.040	24	view →
PDAC	OS	Median	IV	0.937	0.395	.026	8	view →
UCEC	DFS	Median	All	0.930	1.000	.013	4	view →
GBM	DFS	Tertile	All	0.301	0.562	.016	4	view →
LSCC	DFS	Tertile	III,IV	0.483	0.934	.014	3	view →
LUAD	DFS	Median	All	0.954	0.882	.047	1	view →
HNSC	OS	Median	III,IV	1.000	0.948	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CLASP2–CCRCC (DFS)

Open the CCRCC breakdown →