CLASP1

Across TCGA cell cohorts, CLASP1 mutation is significantly associated with the RNA expression of many other genes, with 726 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLASP1-associated genes across cancer lineages are LYG1, HES3, and TMEM244. Each is linked with CLASP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLASP1-to-partner and partner-to-CLASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by CLASP1-low versus CLASP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLASP1→partner) and Y-score (partner→CLASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+1.009	+3.502	<.001	.001	3	3
BLOOD_Lymphoma	HES3 →	+0.125	+4.523	<.001	.004	3	2
LUNG_SCLC	TMEM244 →	+0.465	+3.584	<.001	.003	3	2
BREAST	ADGRD2 →	+0.221	+3.906	<.001	.001	3	2
BLOOD_Leukemia	C12orf57 →	+1.183	+3.614	<.001	<.001	3	2
LARGE_INTESTINE	AP1AR →	+0.683	+3.502	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 726 associations by consensus.

LYG1 by CLASP1 expression — LARGE_INTESTINE

Explore this box plot interactively →