CKS2

Across TCGA patient cohorts, CKS2 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible CKS2-associated genes across cancer lineages are TRAJ40, KRTAP10-3, and MIR1224. Each is linked with CKS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CKS2-to-partner and partner-to-CKS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ40 grouped by CKS2-low versus CKS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKS2→partner) and Y-score (partner→CKS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ40 →	+1.483	+4.326	<.001	.007	3	2
BLCA	KRTAP10-3 →	+0.090	+4.162	<.001	.003	3	1
BLCA	MIR1224 →	+0.335	+4.859	<.001	.004	3	1
BLCA	RPL31P53 →	+0.094	+4.562	<.001	.006	3	1
BLCA	PRPS1P1 →	+0.030	+5.722	<.001	.001	3	1
BLCA	PIGQP1 →	+0.062	+5.033	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

TRAJ40 by CKS2 expression — UCEC

Explore this box plot interactively →