Across TCGA pan-cancer cohorts, CKS1BP5 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CKS1BP5’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where CKS1BP5 RNA is repressed in tumor relative to normal tissue. In most cancer types CKS1BP5 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where CKS1BP5 tumor–normal differential expression is most reproducible.