CKMT2

Across TCGA patient cohorts, CKMT2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CKMT2-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and mTOR_pS2448. Each is linked with CKMT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CKMT2-to-partner and partner-to-CKMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CKMT2-low versus CKMT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKMT2→partner) and Y-score (partner→CKMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.332	+3.169	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.985	+2.341	<.001	.003	3	3
UCEC	mTOR_pS2448 →	-0.171	-3.308	.003	.009	3	2
UCEC	Notch1 →	+0.277	+3.169	<.001	<.001	3	2
UCEC	ATM →	-0.561	-2.502	.001	.002	3	2
UCEC	Bax →	+0.230	+1.584	.014	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PCNA by CKMT2 expression — UCEC

Explore this box plot interactively →