CKM

Across TCGA patient cohorts, CKM protein abundance is significantly associated with the RNA expression of many other genes, with 777 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CKM-associated genes across cancer lineages are LAMA2, TPSB2, and RPL26P9. Each is linked with CKM in more than 1 cancer types. Because this analysis shows association rather than direction, both CKM-to-partner and partner-to-CKM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CKM versus LAMA2 in UCEC, with a Pearson correlation of -0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKM→partner) and Y-score (partner→CKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LAMA2 →	-2.815	-1.387	<.001	.006	3	2
LSCC	TPSB2 →	-2.216	-0.868	.003	.004	3	2
UCEC	RPL26P9 →	-3.117	-1.242	.004	.004	3	2
UCEC	RN7SL803P →	-1.277	-0.945	.001	.007	3	2
UCEC	VRK1 →	+0.902	+1.067	.003	.001	3	1
UCEC	TLDC2 →	-0.790	-0.985	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 777 associations by consensus.

CKM vs LAMA2 — UCEC

Explore this scatter interactively →