CKM

Across TCGA patient cohorts, CKM mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CKM-associated genes across cancer lineages are FOXO3a_pS318_S321, NF-kB-p65_pS536, and p70-S6K_pT389. Each is linked with CKM in more than 1 cancer types. Because this analysis shows association rather than direction, both CKM-to-partner and partner-to-CKM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CKM-low versus CKM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKM→partner) and Y-score (partner→CKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.167	-2.990	.010	.036	3	1
UCEC	NF-kB-p65_pS536 →	-0.608	-2.990	.010	.036	3	1
UCEC	p70-S6K_pT389 →	-0.226	-3.321	.023	.010	3	1
UCEC	Src_pY527 →	-0.654	-3.321	.003	.010	3	1
UCEC	4E-BP1 →	+0.469	+3.321	<.001	.010	3	1
UCEC	PCNA →	+0.331	+3.321	.003	.010	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FOXO3a_pS318_S321 by CKM expression — UCEC

Explore this box plot interactively →