CKM

Across TCGA cell cohorts, CKM RNA expression is significantly associated with the go_rna of many other GO terms, with 1,451 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CKM-associated GO terms across cancer lineages are Regulation of interleukin-6-mediated signaling pathway, Tubulin deacetylation, and Pallium development. Each is linked with CKM in more than 4 cancer types. Because this analysis shows association rather than direction, both CKM-to-partner and partner-to-CKM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of interleukin-6-mediated signaling pathway grouped by CKM-low versus CKM-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CKM→partner) and Y-score (partner→CKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of interleukin-6-mediated signaling pathway →	-0.147	-1.129	<.001	.008	3	5
BONE	Tubulin deacetylation →	+0.099	+0.278	.004	.007	3	5
SKIN	Pallium development →	+0.031	+0.040	.005	.004	3	5
SOFT_TISSUE	Regulation of RNA splicing →	+0.081	+1.501	<.001	.006	3	4
SOFT_TISSUE	Negative regulation of gene expression, epigenetic →	+0.054	+1.138	<.001	.008	3	4
SOFT_TISSUE	Protein insertion into mitochondrial membrane →	+0.059	+1.161	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,451 associations by consensus.

Regulation of interleukin-6-mediated signaling pathway by CKM expression — SOFT_TISSUE

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