CKM

Across TCGA cell cohorts, CKM mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CKM-associated genes across cancer lineages are TBATA, MOGAT2, and OR4N4. Each is linked with CKM in more than 1 cancer types. Because this analysis shows association rather than direction, both CKM-to-partner and partner-to-CKM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBATA grouped by CKM-low versus CKM-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKM→partner) and Y-score (partner→CKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TBATA →	+0.011	+4.357	<.001	.004	3	1
CNS	MOGAT2 →	+0.039	+3.801	.008	.004	3	1
CNS	OR4N4 →	+0.064	+4.058	.002	<.001	3	1
CNS	CYP2A13 →	+0.024	+3.459	<.001	.006	3	1
LARGE_INTESTINE	ENPP6 →	+0.053	+3.793	<.001	.007	3	1
LARGE_INTESTINE	USP17L4 →	+0.012	+4.217	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TBATA by CKM expression — CNS

Explore this box plot interactively →