CKB

Across TCGA pan-cancer cohorts, CKB mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CKB data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CKB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CKB expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where CKB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	1.000	0.903	.004	42	view →
PDAC	OS	Quartile	All	0.719	0.272	.001	38	view →
UCEC	DFS	Tertile	III,IV	0.256	1.000	.002	20	view →
LUAD	OS	Tertile	III,IV	0.298	0.819	.003	19	view →
GBM	OS	Quartile	All	0.173	0.693	<.001	9	view →
CCRCC	DFS	Median	III,IV	0.818	0.564	.023	7	view →
LSCC	DFS	Quartile	All	0.902	0.692	.013	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CKB–HNSC (DFS)

Open the HNSC breakdown →