CKAP5

Across TCGA pan-cancer cohorts, CKAP5 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CKAP5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CKAP5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CKAP5 is over-expressed in tumor.

HNSC, COAD, and KIRP are the cancer types where CKAP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CKAP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+1.299	<.001	12	view →
COAD	Male	All	+1.043	<.001	10	view →
KIRP	All	II,III,IV	+0.743	<.001	10	view →
STAD	Male	II,III,IV	+1.528	<.001	9	view →
LIHC	Female	II,III,IV	+1.204	<.001	9	view →
LUAD	Male	II,III,IV	+1.153	<.001	9	view →
BLCA	All	All	+0.927	<.001	9	view →
LUSC	Male	II,III,IV	+1.645	<.001	8	view →
BRCA	All	III,IV	+0.853	<.001	6	view →
UCEC	All	All	+0.554	.021	6	view →
CHOL	All	All	+1.526	<.001	5	view →
KIRC	All	All	+0.248	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CKAP5–HNSC

Open the HNSC breakdown →