CKAP4

Across TCGA patient cohorts, CKAP4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CKAP4-associated genes across cancer lineages are eIF4E, ERK2, and JNK2. Each is linked with CKAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CKAP4-to-partner and partner-to-CKAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CKAP4-low versus CKAP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKAP4→partner) and Y-score (partner→CKAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.175	+2.584	.030	.010	3	1
UCEC	ERK2 →	+0.178	+3.584	.015	.002	3	1
UCEC	JNK2 →	+0.216	+2.584	.004	.001	3	1
UCEC	Ku80 →	+0.232	+2.009	.010	.017	3	1
UCEC	MSH2 →	-0.257	-2.295	.003	.033	3	1
UCEC	NF2 →	+0.224	+1.700	.007	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4E by CKAP4 expression — UCEC

Explore this box plot interactively →