CKAP4

Across TCGA cell cohorts, CKAP4 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CKAP4-associated genes across cancer lineages are SLC6A5, OR1D2, and RNASE9. Each is linked with CKAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CKAP4-to-partner and partner-to-CKAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC6A5 grouped by CKAP4-low versus CKAP4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKAP4→partner) and Y-score (partner→CKAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC6A5 →	+0.019	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR1D2 →	+0.026	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PNMA6F →	+0.006	+4.887	.009	.009	3	1
BLOOD_Leukemia	PCDH8 →	+0.577	+3.769	.007	.004	3	1
BLOOD_Leukemia	IZUMO3 →	+0.036	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

SLC6A5 by CKAP4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →