CKAP4

Across TCGA cell cohorts, CKAP4 mutation is significantly associated with the mutation status of many other genes, with 4,000 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CKAP4-associated genes across cancer lineages are TPR, USP13, and PKN2. Each is linked with CKAP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CKAP4-to-partner and partner-to-CKAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPR grouped by CKAP4-low versus CKAP4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKAP4→partner) and Y-score (partner→CKAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TPR →	+1.527	+2.807	.005	.005	1	3
LARGE_INTESTINE	USP13 →	+3.222	+5.050	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	PKN2 →	+4.392	+4.954	.008	.008	1	3
BLOOD_Leukemia	SPEN →	+1.997	+2.857	.005	.005	1	3
LARGE_INTESTINE	CLTCL1 →	+2.807	+3.857	<.001	<.001	1	3
LARGE_INTESTINE	PAG1 →	+4.129	+3.536	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,000 associations by consensus.

TPR by CKAP4 expression — LARGE_INTESTINE

Explore this box plot interactively →