CKAP2

Across TCGA patient cohorts, CKAP2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CKAP2-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and 14-3-3_beta. Each is linked with CKAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CKAP2-to-partner and partner-to-CKAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CKAP2-low versus CKAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKAP2→partner) and Y-score (partner→CKAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.512	+2.135	.016	.010	3	3
UCEC	C-Raf →	+0.140	+1.700	.006	.042	3	2
UCEC	14-3-3_beta →	-0.078	-1.847	.032	.049	3	1
UCEC	EGFR_pY1068 →	-0.280	-2.807	.001	<.001	3	1
UCEC	EGFR →	-0.181	-2.433	.001	.018	3	1
UCEC	eIF4E →	+0.201	+3.472	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-7-cleavedD198 by CKAP2 expression — UCEC

Explore this box plot interactively →