CIZ1

Across TCGA patient cohorts, CIZ1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIZ1-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and JNK2. Each is linked with CIZ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CIZ1-to-partner and partner-to-CIZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CIZ1-low versus CIZ1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIZ1→partner) and Y-score (partner→CIZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.828	+3.016	<.001	.018	3	3
UCEC	MEK1 →	+0.446	+1.906	.002	.016	3	2
UCEC	JNK2 →	+0.302	+2.469	<.001	.010	3	1
UCEC	Ku80 →	+0.288	+2.710	.002	.003	3	1
UCEC	MSH2 →	-0.267	-2.295	.004	.033	3	1
UCEC	p62 Lck ligand →	+0.348	+2.331	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by CIZ1 expression — COAD

Explore this box plot interactively →