CITED1

Across TCGA patient cohorts, CITED1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CITED1-associated genes across cancer lineages are STAT3_pY705, ATM, and A-Raf_pS299. Each is linked with CITED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CITED1-to-partner and partner-to-CITED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CITED1-low versus CITED1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CITED1→partner) and Y-score (partner→CITED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.362	-1.807	<.001	.027	3	2
UCEC	ATM →	-0.403	-1.807	.031	.027	3	2
UCEC	A-Raf_pS299 →	-0.111	-1.807	.023	.027	3	1
UCEC	IRS1 →	+0.238	+1.807	.005	.027	3	1
UCEC	JNK2 →	+0.289	+3.710	<.001	<.001	3	1
UCEC	MEK1 →	+0.414	+3.807	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

STAT3_pY705 by CITED1 expression — UCEC

Explore this box plot interactively →