CIT

Across TCGA patient cohorts, CIT RNA expression is significantly associated with the protein abundance of many other proteins, with 24,236 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CIT-associated proteins across cancer lineages are RFC3, SF3B3, and STMN1. Each is linked with CIT in more than 6 cancer types. Because this analysis shows association rather than direction, both CIT-to-partner and partner-to-CIT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CIT versus RFC3 in LSCC, with a Pearson correlation of 0.68.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CIT→partner) and Y-score (partner→CIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC3 →	+0.360	+0.811	<.001	<.001	3	7
LSCC	SF3B3 →	+0.215	+0.783	<.001	<.001	3	7
LSCC	STMN1 →	+0.762	+0.871	<.001	<.001	3	7
BRCA	AURKB →	+1.029	+0.719	<.001	<.001	3	7
LUAD	CIT_S1971 →	+2.102	+1.577	<.001	<.001	3	7
COAD	CTR9 →	+0.215	+0.723	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 24,236 associations by consensus.

CIT vs RFC3 — LSCC

Explore this scatter interactively →