CIT

Across TCGA patient cohorts, CIT protein abundance is significantly associated with the protein abundance of many other proteins, with 32,102 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CIT-associated proteins across cancer lineages are PLIN3, CIT_S1971, and ANLN. Each is linked with CIT in more than 6 cancer types. Because this analysis shows association rather than direction, both CIT-to-partner and partner-to-CIT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CIT versus PLIN3 in GBM, with a Pearson correlation of -0.50.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CIT→partner) and Y-score (partner→CIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLIN3 →	-0.509	-0.646	<.001	<.001	3	7
LUAD	CIT_S1971 →	+2.465	+1.526	<.001	<.001	3	7
BRCA	ANLN →	+0.870	+0.434	<.001	<.001	3	6
BRCA	CAVIN1 →	-0.898	-0.493	<.001	<.001	3	6
OV	RFC1_S368 →	+1.345	+0.654	<.001	<.001	3	6
LSCC	VPS13C →	-0.346	-0.491	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 32,102 associations by consensus.

CIT vs PLIN3 — GBM

Explore this scatter interactively →