CIT

Across TCGA patient cohorts, CIT mutation is significantly associated with the RNA expression of many other genes, with 9,003 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIT-associated genes across cancer lineages are ADNP2, IER3IP1, and RMC1. Each is linked with CIT in more than 4 cancer types. Because this analysis shows association rather than direction, both CIT-to-partner and partner-to-CIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADNP2 grouped by CIT-low versus CIT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIT→partner) and Y-score (partner→CIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADNP2 →	+0.606	+1.454	<.001	<.001	3	5
COAD	IER3IP1 →	+0.659	+2.820	<.001	.001	3	5
CESC	RMC1 →	+0.395	+3.219	.006	.009	3	5
LUAD	PCCB →	+0.507	+3.471	.004	.002	3	5
SKCM	CEP85 →	+0.517	+2.751	<.001	.002	3	5
UCEC	RPA1 →	+0.596	+1.766	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,003 associations by consensus.

ADNP2 by CIT expression — UCEC

Explore this box plot interactively →